Rome is the capital city and a special comune of Italy (named Comune di Roma Capitale). Rome also serves as the capital of the Lazio region. With 2,872,800 residents in 1,285 km2(496.1 sq mi), it is also the country's most populated comune. It is the fourth-most populous city in the European Union by population within city limits. It is the centre of the Metropolitan City of Rome, which has a population of 4,355,725 residents, thus making it the most populous metropolitan city in Italy. Rome is located in the central-western portion of the Italian Peninsula, within Lazio (Latium), along the shores of the Tiber. The Vatican City (the smallest country in the world) is an independent country inside the city boundaries of Rome, the only existing example of a country within a city: for this reason Rome has been often defined as capital of two states.

Rome's history spans 28 centuries. While Roman mythology dates the founding of Rome at around 753 BC, the site has been inhabited for much longer, making it one of the oldest continuously occupied sites in Europe. The city's early population originated from a mix of Latins, Etruscans, and Sabines. Eventually, the city successively became the capital of the Roman Kingdom, the Roman Republic and the Roman Empire, and is regarded as the birthplace of Western civilization and by some as the first ever metropolis. It was first called The Eternal City (Latin: Urbs Aeterna; Italian: La Città Eterna) by the Roman poet Tibullus in the 1st century BC, and the expression was also taken up by Ovid, Virgil, and Livy. Rome is also called the "Caput Mundi" (Capital of the World). After the fall of the Western Empire, which marked the beginning of the Middle Ages, Rome slowly fell under the political control of the Papacy, which had settled in the city since the 1st century AD, until in the 8th century it became the capital of the Papal States, which lasted until 1870. Beginning with the Renaissance, almost all the popes since Nicholas V (1447–1455) pursued over four hundred years a coherent architectural and urban programme aimed at making the city the artistic and cultural centre of the world. In this way, Rome became first one of the major centres of the Italian Renaissance, and then the birthplace of both the Baroque style and Neoclassicism. Famous artists, painters, sculptors and architects made Rome the centre of their activity, creating masterpieces throughout the city. In 1871, Rome became the capital of the Kingdom of Italy, which, in 1946, became the Italian Republic.

Rome has the status of a global city. In 2016, Rome ranked as the 14th-most-visited city in the world, 3rd most visited in the European Union, and the most popular tourist attraction in Italy. Its historic centre is listed by UNESCO as a World Heritage Site. The famous Vatican Museums are among the world's most visited museums while the Colosseum was the most popular tourist attraction in world with 7.4 million visitors in 2018. Host city for the 1960 Summer Olympics, Rome is the seat of several specialized agencies of the United Nations, such as the Food and Agriculture Organization (FAO), the World Food Programme (WFP) and the International Fund for Agricultural Development (IFAD). The city also hosts the Secretariat of the Parliamentary Assembly of the Union for the Mediterranean (UfM) as well as the headquarters of many international business companies such as Eni, Enel, TIM, Leonardo S.p.A., and national and international banks such as Unicredit and BNL. Its business district, called EUR, is the base of many companies involved in the oil industry, the pharmaceutical industry, and financial services. Rome is also an important fashion and design centre thanks to renowned international brands centered in the city. Rome's Cinecittà Studios have been the set of many Academy Award–winning movies.

The capital of Malta - Valletta , is the first and almost the only city in Europe, which was once designed by architects and built according to all the rules and norms of construction. Valletta is considered to be one of the most beautiful cities on the Mediterranean. Klaipeda is on the list of the few remaining fortified towns. The center of the city is the Palace of the Grand Master of the Order of Malta, and today the residence of the President of the country, here is the seat of the Maltese Parliament. The list of places to visit in Valletta includes the Castilla Palace, the Admiralty (where the National Museum of Fine Arts is now located, with the largest painting collection in the country), a charming place in the city - the beautiful Hastings Gardens, and this is not the whole list of the riches of the capital of Malta .

Heraklion or Heraclion is the largest city and the administrative capital of the island of Crete. It is the fourth largest city in Greece. According to the results of the 2011 census, the population of the city proper was 166,209 inhabitants, the municipality's was 173,993 while the Heraklion urban area has a population of 225,574 and it extends over an area of 684.3 km2 (264.2 sq mi).

Heraklion is the capital of Heraklion regional unit.

The Bronze Age palace of Knossos, also known as the Palace of Minos, is located nearby.

Piraeus is the gateway to Athens , which, in turn, is rightfully considered the center of the centers of the whole world, with the main attraction - the acropolis. Piraeus is an old port city serving the port of Athens, the largest port in Greece to date. Piraeus is part of the great Athens, which boasts an abundance of attractions, including unique monuments of national fine art. More than two hundred museums and galleries, including the University History Museum, the Ceramics Archaeological Museum and many others, will hospitably welcome you within their walls and familiarize themselves with the culture of this area.

Volos (Greek: Βόλος) is a coastal port city in Thessaly situated midway on the Greek mainland, about 330 kilometres (205 miles) north of Athens and 220 kilometres (137 miles) south of Thessaloniki. It is the capital of the Magnesiaregional unit. Volos is the only outlet to the sea from Thessaly, the country's largest agricultural region. With a population of 144,449 (2011), it is an important industrial centre, while its port provides a bridge between Europe, the Middle East and Asia.

Volos is the newest of the Greek port cities, with a large proportion of modern buildings erected following the catastrophic earthquakes of 1955. It includes the municipal units of Volos, Nea Ionia and Iolkos, as well as smaller suburban communities. The economy of the city is based on manufacturing, trade, services and tourism. Home to the University of Thessaly, the city also offers facilities for conferences, exhibitions and major sporting, cultural and scientific events. Volos participated in the 2004 Olympic Games, and the city has since played host to other athletic events, such as the European Athletic Championships. Volos hosted the 7th International Olympiad on Astronomy and Astrophysics from 27 July to 5 August 2013.